18 ミナミウシノシタ防禦分泌液中の魚毒性界面活性ペプチド

概要

論文の詳細を見る
Soles of the genus Pardachirus possess ichthyotoxic defense secretion. Three homologous peptides, pardaxin P-1 (1), pardaxin P-2 (2), and pardaxin P-3 (3), have been isolated from the secretion of P. pavoninus, where the ichthyotoxic and shark repellent steroid glycosides, pavoninins, had already been isolated. The amino acid sequence of each pardaxin P, a linear peptide comprising 33 conventional amino acid residues, was obtained as shown in Fig. 3 by means of an automated Edman degradation, and was corroborated by solid-phase synthesis thereof. The peptides are ichthyotoxic, hemolytic, and markedly surfactant. They are also indicated to be shark repellent. The surfactant property is clearly indicated by their amphiphilic sequences and also by their probable secondary structures. These peptides show physical, pharmacological, and structural similarities to a bee venom, melittin, and are expected to constitute a good pharmacological tool, when used in combination with melittin, to probe mechanisms of action involving permeabilization of phospholipid bilayer membranes.
天然有機化合物討論会の論文
1986-09-09