A Myomodulin-CARP-related Peptide Isolated from a Polychaete Annelid, Perinereis vancaurica
スポンサーリンク
概要
- 論文の詳細を見る
Myomodulin-CARP-family peptides have been isolated only from molluscs. In the present study, a heptapeptide, Ala-Met-Gly-Met-Leu-Arg-Met-NH_2, termed Pev-myomodulin, was isolated from a polychaete annelid, Perinereis vancaurica using the esophagus of the animal as the bioassay system. The sequence of the annelid peptide is highly homologous with those of the myomodulin-CARP-family peptides found in molluscs. The annelid peptide is regarded as a member of the myomodulin-CARP family, though all the molluscan peptides have a Leu-NH_2 at their C-termini. The annelid peptide showed a potnet contractile action on the esophagus of the annelid. The peptide may be an excitatory neuromediator involved in the regulation of the esophagus. Among various myomodulin-CARP-family peptides and their analogues, the annelid peptide showed the most potent contractile action on the esophagus. Replacement of the C-terminal Met-NH_2 of the annelid peptide with a Leu-NH_2 decreased its contractile potency, while replacement of the C-terminal Leu-NH_2 of myomodulin and CARP with a Met-NH_2 increased their potency. The C-terminal Met-NH_2 of the annelid peptide seems to be important, but not essential, for exhibiting its contractile activity on the esophagus. On the anterior byssus retractor muscle of the bivalve mollusc Mytilus edulis, the annelid peptide showed catch-relaxing and contraction-modulating effects qualitatively similar to those of the authentic peptide CARP, though the annelid peptide was less potent than CARP.
- 社団法人日本動物学会の論文
- 1994-02-15
著者
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MINAKATA Hiroyuki
Suntory Institute for Bioorganic Research
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南方 宏之
(財)サントリー生有研
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Fujimoto Masaaki
Department of Biological Science, Faculty of Life and Environmental Science, Shimane University
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NOMOTO Kyosuke
Suntory Institute for Bioorganic Research
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Ikeda Tetsuya
Suntory Institute For Bioorganic Research
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Matsushima Osamu
Department of Environmental Information Faculty of Environmental Study Hiroshima Institute of Techno
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Nomoto K
Suntory Institute For Bioorganic Research
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Nomoto Kyosuke
Suntory Institute For Bioorganic Reseach
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MORISHITA Fumihiro
Department of Biological Science, Graduate School of Science, Hiroshima University
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南方 宏之
財団法人サントリー生物有機科学研究所
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Matsushima Osamu
Fuculty Of Environmental Studies Hiroshima Institute Of Technology
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Fujimoto Masaaki
Department Of Biological Science Faculty Of Life And Environmental Science Shimane University
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Ikeda Tetsuya
Division Of Neurobiology Department Of Anatomy School Of Medicine Faculty Of Medicine University Of
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TAKAHASHI Toshio
Faculty of Engineering, The University of Tokyo
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Fujimoto M
Department Of Biological Science Faculty Of Life And Environmental Science Shimane University
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Morishita F
Department Of Biological Science Hiroshima University
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Morishita Fumihiro
Department Of Biological Science Graduate School Of Science Hiroshima University
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Takahashi Toshio
Faculty Of Integrated Arts And Sciences Hiroshima University
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Minakata Hiroyuki
Suntory Foundation For Life Sciences
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