高代謝速度臓器再構築を目的とした3次元担体の水溶性フィラを援用した粉末焼結積層造形法 : 微細流路ネットワークが配置された生分解性ポリマ製多孔質体の造形

概要

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Fabrication of very porous scaffold for regeneration of organs with high metabolic rate is reported. Polycaprolactone (PCL) powder was mixed with fine grains of sodium chloride as filler and SLS (Selective Laser Sintering) processed to develop an object including fine flow channel network. The object was rinsed with water to desolve the salt, and a high porosity of 90% was successfully obtained. In addition, unsintered powder in the channels was effectively removed owing to disappearance of the filler. Through micro-CT observation, it was confirmed that channels of which diameter was smaller than 1mm were fabricated. Measurement for the amount of residual salt proved that the salt can increase salt concentration of culture media no more than 1% of that for physiological saline solution. Result of culture test is also reported.
公益社団法人精密工学会の論文
2007-11-05