Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium BGE. I(Pharmacognosy,Chemical)
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概要
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When the CHCl_3 extract obtained by partitioning the methanolic extract of Periploca sepium between H_2O, and CHCl_3 was subjected to column chromatography on silica gel, the antitumor activity against Sarcoma 180 ascites in mice was concentrated in the fraction eluted with CHCl_3-MeOH (10:1). From the antitumor fraction, eight products, S-1--S-8, were isolated. S-1 was identified as 12β-hydroxypregna-4,6,16-triene-3,20-dione (neridienone-A), obtained for the first time from AscIepiadaceous plants, by direct comparison with an authentic sample and the others were found to be steroidal glycosides. A new compound S-2A (named periplocogenin), and two known aglycones S-3A and S-5A, obtained by hydrolyzing the above glycosides with diluted acid, were respectively identified as 3β-0-(4',6'-dideoxy-3'-O-methyl-Δ^3-D-2'-hexosulosyl)-Δ^5-pregnene-17α,20(S)-diol, periplogenin, and Δ^5-pregnene-3β,20(S)-diol from the proton and carbon-13 nuclear magnetic resonance spectral data. The structure of S-6A was identical with that of S-5A, and S-7A and S-8A were identical with S-2A.
- 公益社団法人日本薬学会の論文
- 1987-11-25
著者
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糸川 秀治
Tokyo College Of Pharmacy
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糸川 秀治
東京薬科大学 薬学部
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竹谷 孝一
Tokyo College of Pharmacy
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徐 俊平
Tokyo College of Pharmacy
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