眼瞼閉鎖ラットの形態学 : 2.無眼球症(保健科学部)

概要

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Many anomalies of the visual system, bilateral anophthalmos, unilateral anophthalmos and optic nerve degeneration seem to be closely related to microphthalmos were found in KUHW-rats derived from a Wistar strain inbred colony. Nevertheless the rats have no recognizable eye and optic nerve in both sides were completely missing, their eyelids and optic tracts were present in anophthalmos rats. Diffuse axonal degeneration of the optic nerve on the affected side and contra-lateral optic tract were observed in microphthalmos rats. Breeding and morphological studies were undertaken to determine the nature of the ocular defect, as well as its cause and pathogenesis. These anomalies were found to be inherited as an autosomal recessive trait with variable expressivity. The studies of the prenatal morphogenesis of the microphthalmos suggested that the primary disorder reflects a disturbance of the neuroepithelium of the retinal anlage and results in defective early formation of the optic cup. Microphthalmos and anophthalmos are congenital ocular malformations that may create eyelid malformations because of the absence of the globe's trophic effects on the growth of the lids and orbit. It is particularly relevant in understanding the pathogenesis of microphthalmos in the human eye.
2006-03-25