視床-線条体系における視床下核の役割に関する新たな視点

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Current concepts for the role of the pars compacta of the substatia nigra (SNc) consider that the output neurons of this ganglion supply the dopamine to the two antagonistic pathways in the corpus striatum (St). One of them inhibits the pars reticulata of the substantia nigra (SNr) and the internal segment of the globus pallidus (GPi), in which the output neurons release the signal that inhibit the action of the thalamic nuclei. Another one inhibits the inhibiting neurons to the external segment of the globus pallidus (GPe), which release the inhibiting signals to the subthalamic nucleus (STN). These pathways are so-called the direct and the indirect pathway, respectively. It is mysteriously that same signals effect to incompatible pathways, the stimulating and inhibiting. Greenstein indicated the efferent projection of the SNC to the St, which involved the collateral branch to the Gpe in his edition. If it were true, it is doubtful that SNC is the origin of the indirect pathway. Because both pathways made passing through the antagonistic signals each other to the Gpe. Our conception is that direct pathway is feed forward pathway stimulating the cortex but inhibiting pathway is hyperdirect pathway, so called Kita and others. In this pathway, the output signals of the STN not only send to the SNr and the CPi, but to the CPe. The projection from the STN to the GPe stimulates the inhibiting neurons to the STN. This loop effects as a negative feed back (NFB) function against the STN and the projection of the St to the GPe, is thought an inhibiting signals to this NFB circuit.
九州保健福祉大学の論文
2004-03-25

視床-線条体系における視床下核の役割に関する新たな視点

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