多発性筋炎の経過中に膜性腎症によるネフローゼ症候群を伴った1例

概要

論文の詳細を見る
A 49-year-old man was admitted to Kitasato University Hospital to treat nephrotic syndrome developing during the course of polymyositis in April 4, 1996. On admission, general edema and hypertension of 150/90 mmHg were observed. Laboratory findings were as follows: urinary protein 5.6 g/day, urinary occult blood (l), TP 3.9 g/dl, serum albumin 1.8 g/dl, total cholesterol 592 mg/dl, creatinine 0.7 mg/dl, Ccr 84 ml/min, LDH 575 IU/l, CPK 367 IU/l, aldolase 15.6 mIU/ml, ANA (-), anti-DNAab<2.5 IU/l, CH50 36 U/ml. Renal biopsy revealed membranous nephropathy. On electron microscopy, virus-like particles which suggest presence of collagen diseases was found in glomerular endothelial cytoplasma. Search for malignancy, coexistence of other collagen diseases, and various types of infection showed negative results. These results suggest that in the present case membranous nephropathy occurred in association with polymyositis, although renal involvement rarely develops in the course of polymyositis.
北里大学の論文
1999-12-31