Spectrophotometric Studies on Hydroxamic Acid-Borate and Aluminate Complex
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概要
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Borate was found to prevent or reverse remarkably the inhibition of urease activity by hydroxamic acids. Based on these facts, formation of hydroxamic acid-borate complex was studied spectrophotometrically. 1. All the metal ions tested except boric ion showed little protective effect against hydroxamate-inhibition of urease activity. 2. Characteristic absorption maximum of benzohydroxamic acid-borate complex was observed at 265 nm in the pH range from 8 to 11. The investigation of pH effect on the ultraviolet absorption of the complex suggests that keto form of hydroxamic acidborate complex is tautomerized to imidol-borate complex around neutral pH, which is dissociated to the imidol anion and borate in a more alkaline pH range than 11. Aluminate is assumed spectrophotometrically to form the similar complex with benzohydroxamic acid, though it did not prevent the inhibition of urease activity by hydroxamic acid. 3. Based upon these observations, we proposed new spectrophotometric methods of determination of benzohydroxamic acid, borate and aluminate.
- 公益社団法人日本薬学会の論文
- 1973-10-25
著者
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小橋 恭一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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小橋 恭一
富山医薬大薬学部
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長谷 純一
Faculty of Pharmaceutical Sciences, University of Toyama
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寺島 信雄
Faculty Of Pharmaceutical Sciences University Of Toyama
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長谷 純一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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