Inhibition of Helicobacter pylori Urease Activity by Hydroxamic Acid Derivatives
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概要
- 論文の詳細を見る
Helicobacter pylori (HP) produces strong urease [EC 3.5.1.5], which is considered to play a role in the pathogenesis of gastritis and peptic ulcers. Inhibitions against this enzyme have been studied with hydroxamic acid (HXA) derivatives of aliphatic or aromatic carboxylic acids, amino acids and dipeptides. A number of HXAs potently inhibited the urease (I_<50> values were near the order of 10^<-6>M), and H-Ile-Gly-NHOH (I_<50>=0.20×10^<-6>M) was the most potent inhibitor among the derivatives. HP urease was inhibited more potently, in general, than Jack bean (JB) urease by HXAs, and a correlation between the chemical structures of HXA derivatives and their inhibitory effects on HP urease was observed, in comparison with JB urease.
- 1994-10-15
著者
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小橋 恭一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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今村 理佐
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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小竹 慎二郎
Research Institute, Fuji Chemical Industries, Ltd.
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森川 忠則
Research Institute, Fuji Chemical Industries, Ltd.
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今村 理佐
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Tsuchiya M
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
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小竹 慎二郎
Research Institute Fuji Chemical Industries Ltd.
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土谷 満美子
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Kobayashi K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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森川 忠則
Research Institute Fuji Chemical Industries Ltd.
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Tsuchiya M
Chiba Univ. Chiba Jpn
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土谷 満美子
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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