Silymarin and Its Components Are Inhibitors of β-Glucuronidase
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概要
- 論文の詳細を見る
Silymarin, a commercial crude drug used as a hepatoprotective, was found to inhibit 53% of β-glucuronidase activity at a final concentration of 0.8 mg/ml. Of three compounds A, silybin and C, which were isolated from silymarin, A and silybin potently inhibited the enzyme activity, followed by C. β-Glucuronidases of intestinal bacteria, HGU-1 and HGU-2,and E. coli HB101 were noncompetitively inhibited by silybin. β-Glucuronidase of the feces of a healthy human and of a human with colon cancer were also inhibited by silybin, silymarin and saccharic acid 1,4-lactone at 0.03-0.15 mg/ml. Silymarin and silybin protected the increase in enzyme activity in the serum of the rats treated with CCl_4.
- 社団法人日本薬学会の論文
- 1994-03-15
著者
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小橋 恭一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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金 東鉉
College Of Pharmacy Kyung-hee University
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金 東鉱
College Of Pharmacy Kyunghee University
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陳 映昊
College of Pharmacy Kyung-Hee University
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朴 鍾伯
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Kobayashi K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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朴 鍾伯
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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