Sulfation of Phenolic Antibiotics by Sulfotransferase Obtained from a Human Intestinal Bacterium
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概要
- 論文の詳細を見る
Novel sulfotransferase which was isolated from Eubacterium A-44,a human intestinal bacterium, sulfated phenolic antibiotics, such as amoxicillin, ceaodroxil and cefoperazone. The K_m values of sulfotransferase for these antibiotics were 6.9,4.3 and 22.2 mM, respectively. The V_<max> values were 8.3,3.3 and 1.6 μmol/min/mg protein. The optimal pH of the enzyme was 9.0,a weakly alkaline region. The antibacterial activity of amoxicillin was not altered by enzymic sulfation of the phenolic hydroxyl group.
- 社団法人日本薬学会の論文
- 1992-04-25
著者
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小橋 恭一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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金 東鉉
College Of Pharmacy Kyung-hee University
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Yoon Hae-kyung
Kyung-hee University College Of Pharmacy
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古泉 素明
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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金 東鉱
College Of Pharmacy Kyunghee University
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金 東鉉
Kyung-Hee University, College of Pharmacy
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Kobayashi K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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古泉 素明
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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