Evaluation of Effects of Novel Urease Inhibitor, N-(Pivaloyl)glycinohydroxamic Acid on the Formation of an Infection Bladder Stone Using a Newly Designed Urolithiasis Model in Rats
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概要
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By using our new infection stone model of a rat, we evaluated the effect of a novel urease inhibitor, N-(pivaloyl)glycinohydroxamic acid (P-GHA), on the formation of an infection bladder stone. The oral dosing of P-GHA significantly inhibited the elevation of the urinary ammonia level of rats having the urinary tract infection with Proteus mirabilis.A short term regimen (7d, 730±38 mg/kg) with P-GHA significantly inhibited the development of the infection bladder stone. Furthermore, a long term combination regimen (11 d) of P-GHA and aminobenzylpenicillin markedly inhibited the development of the infection bladder stone, and also caused a very slight renal impairment to the rats tested in contrast with the method of Vermeulen et al.Our infection stone model in rats, therefore, seems to be useful for the evaluation of therapeutic agents in long term examinations.
- 社団法人日本薬学会の論文
- 1991-04-25
著者
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佐藤 勝
エーザイ株式会杜東京研究所
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宗像 敬一
エーザイ株式会杜東京研究所
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小橋 恭一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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竹部 幸子
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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竹部 幸子
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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佐藤 勝
Eisai Research Laboratories
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宗像 敬一
Eisai Research Laboratories
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竹内 秀雄
Department of Urology, Faculty of Medicine, Kyoto University
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吉田 修
Department of Urology, Faculty of Medicine, Kyoto University
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Kobayashi K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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