Effects of a Novel Urease Inhibitor, N-(Diaminophosphinyl)isopentenolamide on the Infection Stone in Rats
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概要
- 論文の詳細を見る
We evaluated the effect of a novel potent urease inhibitor, N-(diaminophosphinyl)isopentenoylamide (IPA), on the development of an infection bladder stone using our urolithiasis model in rats. IPA was excreted into urine after oral administration to rats, and the cumulative urinary recovery rate of unchanged IPA reached about 29.6% within 24 h (50 mg/kg). The oral administration of IPA (6.25 mg/kg, b.i.d., 5d) significantly inhibited the development of the infection bladder stone. The present result suggests that IPA is a very promising compound in the prevention of formation and recurrence of an infection stone owing to a high efficacy and a low toxicity of IPA in animals.
- 社団法人日本薬学会の論文
- 1991-04-25
著者
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佐藤 勝
エーザイ株式会杜東京研究所
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宗像 敬一
エーザイ株式会杜東京研究所
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小橋 恭一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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竹部 幸子
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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竹部 幸子
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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佐藤 勝
Eisai Research Laboratories
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宗像 敬一
Eisai Research Laboratories
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竹内 秀雄
Department of Urology, Faculty of Medicine, Kyoto University
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吉田 修
Department of Urology, Faculty of Medicine, Kyoto University
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Kobayashi K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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