Vertebrate Collagenase Inhibitor. I. : Tripeptidyl Hydroxamic Acids
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概要
- 論文の詳細を見る
A series of tripeptidyl analogues carrying hydroxamic acid residue at the C-terminus of the molecule were synthesized, and their inhibitory activities against vertebrate collagenase and other metalloenzymes including bacterial collagenase were examined. Both Z-Pro-Leu-Ala-NHOH and Z-Pro-D-Leu-D-Ala-NHOH showed highly specific and potent inhibitory activity against tadpole and human skin collagenases with an IC_<50> of 10^<-6> M order.
- 社団法人日本薬学会の論文
- 1990-04-25
著者
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永井 裕
高研バイオサイエンス研究所
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堀 久枝
東京医科歯科大学難治疾患研究所異常代謝部門
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服部 俊治
Department Of Tissue Physiology Medical Research Institute Tokyo Medical And Dental University
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小竹 慎二郎
Research Institute, Fuji Chemical Industries, Ltd.
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岡山 徹
Research Institute, Fuji Chemical Industries, Ltd.
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尾畑 雅美
Research Institute, Fuji Chemical Industries, Ltd.
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森川 忠則
Research Institute, Fuji Chemical Industries, Ltd.
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堀 久枝
Department of Tissue Physiology, Medical Reseach Institute, Tokyo Medical and Dental University
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永井 裕
Department of Tissue Physiology, Medical Reseach Institute, Tokyo Medical and Dental University
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小竹 慎二郎
Research Institute Fuji Chemical Industries Ltd.
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岡山 徹
富士薬品工業(株)研究部
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森川 忠則
Research Institute Fuji Chemical Industries Ltd.
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岡山 徹
Research Institute Fuji Chemical Industries Ltd.
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尾畑 雅美
Research Institute Fuji Chemical Industries Ltd.
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