環境汚染物質の酵素阻害

概要

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Investigations were made on the effect of pollutants such as ethyl and phenyl-mercury, inorganic mercuric ion, cadmium ion, PCB (Kanechlor 300,400,500,600), hexachlorophene, and fluoride on the activity of some enzymes, and the stability of membrane of lysosome and erythrocytes. All the organic and inorganic mercurials strongly inhibited Na^+, K^+-ATPase, FDP-aldolase and urease, and there were no differences among these mercurials in their inhibitory power and in the effect of sulfhydryl compounds on their inhibition. Inorganic mercuric ion disrupted potently the membranes of lysosomes and erythrocytes, but organic mercury ions did not. PCB did not inhibit the enzyme tested of simple protein, but inhibited Na^+, K^+-ATPase which has been known to contain phospholipids as its constituents. This inhibition was completely protected by the addition of lecithin, and PCB was comfirmed to be a lipophilic inhibitor. Hexachlorophene also showed the same type of inhibition as PCB except that it inhibited potently FDP-aldolase Fluoride was inhibitory on Na^+K^+-ATPase and urease activity.
公益社団法人日本薬学会の論文
1974-10-31