Synthesis of Potential Anticancer Agents. II. Halogenation of 7-Substituted 5-Methyl-s-triazolo [2,3-a] pyrimidines

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概要

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• Halogenation of 5-methyl-7-hydroxy- and 5-methyl-7-amino-s-triazolo [2,3-a] pyrimidines with chlorine or bromine gave teh corresponding 6-halogeno derivatives (IX), (X), (XIII), and (XIV). 5-Methyl-6-halo-7-hydroxy derivatives (IX and X) were transformed to the corresponding 6-halo-7-chloro derivatives (VI and XI), which were converted into some 7-substituted 6-halogeno derivatives (XIII, XIV, XV, and XVI) by the usual nucleophilic substitution. Some of these compounds showed biological activity.

• 公益社団法人日本薬学会の論文
• 1959-12-20

著者

• 尾形 秀

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 牧角 徳夫

  Research Laboratory, Shionogi & Co., Ltd.

• 加納 日出夫

  Research Laboratory, Shionogi & Co., Ltd.

• 高橋 史郎

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 高橋 史郎

  Research Laboratory, Shionogi & Co., Ltd.

• 尾形 秀

  Research Laboratory, Shionogi & Co., Ltd.

• 加納 日出夫

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 加納 日出夫

  Research Laboratory Shionogi & Co. Ltd.

• 牧角 徳夫

  Shionogi Research Laboratories Shionogi & Co. Ltd.

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