The in Vitro Metabolism of 3-(1-Hydroxy-2-piperidinoethyl)-5-phenyl-isoxazole Citrate (31252-S) with Rabbit Liver Homogenate
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概要
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The in vitro metabolism of generally labelled ^3H-3-(1-hydroxy-2-piperidinoethyl)-5-phenylisoxazole (^3H-31252-S) using the 9000xg supernatant fraction of rabbit liver homogenate was studied. The metabolites were indentified and determined quantitatively by reverse isotope dilution analysis. The results indicated that it was extensively metabolized and the main metabolic pathways were N-oxidation of piperidine and p-hydroxylation of phenyl ring. 3-{1-Hydroxy-2-(4-hydroxypiperidino) ethyl}-5-phenylisoxazole (XVII) showed slightly stronger analgesic activity than the parent compound 31252-S. All metabolites were less foxic than the parent 31252-S.
- 公益社団法人日本薬学会の論文
- 1976-08-25
著者
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高橋 史郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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高橋 史郎
Shionogi Research Laboratory Shionogi & Co. Ltd.
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橋本 進一郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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志津 三千代
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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橋本 進一郎
Shionogi Research Laboratory Shionogi & Co. Ltd.
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志津 三千代
Shionogi Research Laboratory Shionogi & Co. Ltd.
関連論文
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- The in Vitro Metabolism of 3-(1-Hydroxy-2-piperidinoethyl)-5-phenyl-isoxazole Citrate (31252-S) with Rabbit Liver Homogenate
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