Studies on Heteroaromatic N-Oxides. IX. The Synthesis and Structure of Benzothiazole N-Oxides
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概要
- 論文の詳細を見る
Several benzothiazole 3-oxides were synthesized by N-oxidation of parent bases with organic peracids. Among the oxidizing reagents, monopermaleic acid gave the best result. On oxidation of 6-substituted benzothiazoles, substituents in the 6-position affect yields of the N-oxides ; electrondonating groups caused increase in the yields and electronattractive groups did decrease. Benzothiazoles bearing a functional group in the 2-position could not be oxidized to the N-oxides only to be hydrolyzed or recovered on the treatment with monopermaleic acid. In order to decide that the oxidized benzothiazoles are N-oxides and not S-oxides, dipole moments were measured.
- 公益社団法人日本薬学会の論文
- 1969-08-25
著者
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高橋 史郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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加納 日出夫
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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高橋 史郎
Shionogi Research Laboratory Shionogi & Co. Ltd.
-
加納 日出夫
Shionogi Research Laboratory Shionogi & Co. Ltd.
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