Synthesis of Potential Anticancer Agents. III. 7-Substituted s-Triazolo [2,3-a]-pyrimidines and their Halogenated Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Six kinds of 7-substituted s-triazolo [2,3-a] pyrimidines, which are related to some isomeric compounds of natural purines and their antagonists, were prepared. Halogenation of 7-hydroxy- and 7-amino-s-triazolo [2,3-a] pyrimidines with chlorine or bromine gave the corresponding 6-halogeno derivatives (VII), (VIII), (XI), and (XII). Some other 7-substituted 6-halogeno derivatives (XI), (XII), (XIII), and (XIV) were also derived from (IX) and (X) by the usual substitution reactions. Some of these compounds showed biological activity.
- 公益社団法人日本薬学会の論文
- 1959-12-20
著者
-
牧角 徳夫
Research Laboratory, Shionogi & Co., Ltd.
-
加納 日出夫
Shionogi Research Laboratory Shionogi & Co. Ltd.
-
加納 日出夫
Research Laboratory Shionogi & Co. Ltd.
-
牧角 徳夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
関連論文
- On the Action of Substituted Azaindolizines on Microorganisms. III. Action of Aminated Azaindolizines on Lactic Acid Bacteria.
- Action of Substituted Azaindolizines on Microorganisms. I. Action on Lactic Acid Bacteria.
- Studies on Fused Indoles. II. Structural Modifications and Analgesic Activity of 4-Aminomethyltetrahydrothiopyrano [2,3-b] indoles
- Phenothiazine Derivatives. II. Formation of Polychlorophenothiazines from Diphenylamines with Thionyl Chloride.
- Phenothiazine Derivatives. I. Synthesis of Sulfoxide and Sulfone Homologs of Chlorpromazine.
- Organic Photochemical Reactions. VII. Photolysis of 1-Benzyl-2-ethylbenzimidazole 3-Oxide
- 2-トリアゾリルシクロアルカノール誘導体の立体および光学異性体の抗菌および植物生長阻害活性
- Studies on Heteroaromatic N-Oxides. XI. Aminolysis of Esters of Benzazole N-Oxides and Related Quaternary Salts
- Heteroaromatic N-Oxides. X. Synthesis and Reactions of Benzothiazole 3-Oxide
- Studies on Heteroaromatic N-Oxides. IX. The Synthesis and Structure of Benzothiazole N-Oxides
- Benzimidazole N-Oxides. VIII. The Reactivity of Ethyl 1-Methyl-2-benzimidazolecarboxylate 3-Oxide and the Related Compounds
- Benzimidazole N-Oxides. VII. The Reactivity of 1,2-Dimethylbenzimidazole 3-Oxide
- Benzimidazole N-Oxides. VI. Reaction of 3-Methoxy-1-methyl- and 1,2-dimethyl-benzimidazolium Iodide with Various Nucleophiles
- Benzimidazole N-Oxides. IV. 1,3-Dipolar Cycloaddition Reaction with 1-Methylbenzimidazole 3-Oxide
- Benzimidazole N-Oxides. III. The Reactivity of 1-Methylbenzimidazole 3-Oxide
- Benzimidazole N-Oxides. I. The Structure of Benzimidazole N-Oxide and Synthesis of its Derivatives.
- Synthesis of Potential Anticancer Agents. II. Halogenation of 7-Substituted 5-Methyl-s-triazolo [2,3-a] pyrimidines
- Pyridazines. VIII. Syntheses and Nuclear Magnetic Resonance Spectra of Cinnoline N-Oxides.
- Proton Magnetic Resonance Spectra of the Benzazine and Benzodiazine N-Oxides
- Pyridazines. IV. Nuclear Magnetic Resonance Studies of Pyridazine N-Oxide and Its Derivatives.
- Pyridazines. III. The Dipole Moments and the Structures of Monomethylpyridazine N-Oxides.
- Pyridazines. II. 4-Methylpyridazine N-Oxides.
- Pyridazines. I. 3-Methylpyridazine N-Oxides.
- Synthesis of Cinnoline N-Oxides
- Indole Grignard Reaction. III. : Synthesis, Crystal Structure, and Aalgesic Activity of (R)-and (S)-3-Amino-2,3,4,9-tetrahydrothiopyrano[2,3-b]indoles
- Studies on Fused Indoles. I. Novel Synthesis of 4-Aminomethyltetrahydrothiopyrano [2,3-b] indoles through a Thio-Claisen Rearrangement
- A New Indole Synthesis via Rearrangements of N-Propargylaniline N-Oxides. A One-pot Synthesis of Indole-3-acetonitriles
- The Claisen Rearrangement in Aromatic Heterocyclic Compounds. II. The Thermal Rearrangement of Allyl 4-Quinolyl Ethers
- The Claisen Rearrangement in Aromatic Heterocyclic Compounds. I. The ortho-Claisen Rearrangement of Allyl, Methallyl, and Crotyl Ethers of 2-Methyl-4-quinolinol
- Studies on Azaindolizine Compounds. XVIII. Proton Magnetic Resonance Spectra of s-Triazolo-[1,5-α] pyrimidine and its Derivatives.
- Studies on Azaindolizine Compounds. XVI. The Allyl Rearrangement of 7-Allyloxy-5,6-dimethyls-triazolo [1,5-a] pyrimidime.
- Studies on Azaindolizine Compounds. XV. The Allyl Rearrangement of 5-Methyl-7-allyloxys-triazolo [1,5-a] pyrimidine.
- Studies on Azaindolizine Compounds. XIV. Transetherification in s-Triazolo [1,5-a] pyrimidines.
- Studies on the Azaindolizine Compounds. XIII. Alkylation of 5-Methyl-s-triazolo [1,5-a] pyrimidin-7-ol.
- Studies on the Azaindolizine Compounds. XII. Alkyl Rearrangement of 5-Methyl-7-alkoxy-s-triazolo [1,5-a] pyrimidines.
- Studies on the Azaindolizine Compounds. XI. Synthesis of 6,7-Disubstituted Pyrazolo [1,5-a] pyrimidines.
- Studies on the Azaindolizine Compounds. X. Synthesis of 5,7-Disubstituted Pyrazolo [1,5-a] pyrimidines.
- Synthesis of Potential Anticancer Agents. IX. Condensation of some 2-, 5-, and 7-Methyl-s-triazolo [2,3-α] pyrimidines with Benzaldehyde.
- Synthesis of Potential Anticancer Agents. VIII. 6-Phenylazo-s-triazolo [2,3-α] pyrimidines.
- Synthesis of Potential Anticancer Agents. VII. 6-Nitro- and 6-Amino-s-triazolo [2,3-α] pyrimidines.
- Synthesis of Potential Anticancer Agents. VI. Reactivity of 6-Bromo-s-triazolo [2,3-a] pyrimidines.
- Synthesis of Potential Anticancer Agents. V. 6-Halo-s-triazolo [2,3-a] pyrimidines.
- Synthesis of Potential Anticancer Agents. IV. 5,7-Disubstituted s-Triazolo [2,3-a] pyrimidines.
- Isoxazoles. XVI. The Reaction of Nitrous Acid on 5-Amino-3,4-dialkylisoxazoles
- A New Rearrangement of 3-Diazoaminoisoxazoles
- Isoxazoles. XXIII. Synthesis of N-Substituted 4-Isoxazolines and Their Conversion into 2-Acylaziridines
- Isoxazoles. XXII. A New Synthesis of 4-Isoxazolines and Their Thermal Conversion into Pyrroles
- Isoxazoles. XX. Base-induced Ring Cleavage Reactions of 2,3,4-Trisubstituted Isoxazolium Salts
- Isoxazoles. XIX. Synthesis and Cleavage Reaction of Some 3,4-Disubstituted Isoxazoles
- Separation and Structure of 3-Methylpyridazine 1-Oxide and 2-Oxide
- Synthesis of Potential Anticancer Agents. III. 7-Substituted s-Triazolo [2,3-a]-pyrimidines and their Halogenated Compounds
- Synthesis of Potential Anticancer Agents. I. 5-Substituted 7-Methyl-s-triazolo [4,3-α]-and-tetrazolo [1,5-α]-pyrimidines.
- Studies on Isoxazole Derivatives. XI. Synthesis of 4-Ethoxycarbonyl-and 4-Cyano-5-aminoisoxazoles and Their Ring Cleavage.
- Isoxazole誘導体の研究(第8報)5-Aminoisoxazole類の接触還元