Indole Grignard Reaction. III. : Synthesis, Crystal Structure, and Aalgesic Activity of (R)-and (S)-3-Amino-2,3,4,9-tetrahydrothiopyrano[2,3-b]indoles
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概要
- 論文の詳細を見る
Both enantiomers of the title compounds were synthesized and the crystal structure of one them was determined by X-ray crystallography. The indole Grignard reaction was effective for synthesizing the key intermediate of the (R)-isomers. The analgesic activities of the products were compared with those of 4-methylaminomethyl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole (1), Isoxal^[○!R]. and Tiavamide^[○!R]. The (R)-isomers were more potent than the corresponding (S)-isomers, and were more potent than Isoxal and Tiaramide, but less potent than 1.
- 公益社団法人日本薬学会の論文
- 1990-05-25
著者
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石塚 夏樹
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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佐藤 友宏
Shionogi Research Laboratories
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牧角 徳夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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石塚 夏樹
Shionogi Research Laboratories Shionogi & Co. Ltd.
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