Synthesis of Potential Anticancer Agents. VII. 6-Nitro- and 6-Amino-s-triazolo [2,3-α] pyrimidines.
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概要
- 論文の詳細を見る
By nitration of s-triazolo [2,3-α] pyrimidine derivatives, four kinds of 6-nitro derivatives (Va, VIa, VIIa, and VIIIa) were obtained. These nitro compounds were converted to the corresponding 6-amino derivatives by catalytic reaction and the nature of the amino group at 6-position was examined. 2-Acetamido-1,3-dicarbonyl compounds were condensed with 5-amino-s-triazole (IX) into 6-acetamido-s-triazolo [2,3-α] pyrimidines (VIc, VIIc, and VIIIc), which were converted into the corresponding 6-amino derivatives by hydrolysis.
- 公益社団法人日本薬学会の論文
- 1961-11-25
著者
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牧角 徳夫
Research Laboratory, Shionogi & Co., Ltd.
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牧角 徳夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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