Studies on Fused Indoles. II. Structural Modifications and Analgesic Activity of 4-Aminomethyltetrahydrothiopyrano [2,3-b] indoles
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概要
- 論文の詳細を見る
A series of 4-aminomethyl-2,3,4,9-tetrahydrothiopyrano [2,3-b] indole derivatives was synthesized and evaluated for analgesic activity. Preliminary structure-activity relationship analysis showed that substitution on the benzene portion of the indole ring reduced the analgesic activity, whereas a short-chain N^b-alkyl substituent enhanced the potency, as exemplified by an N^b-methyl substituted analogue. This compound was equipotent to morphine in the acetic acid writhing assay using mice.
- 社団法人日本薬学会の論文
- 1984-03-25
著者
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浅沼 富士夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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畠山 久男
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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高田 進
Shionogi Research Laboratories Shionogi & Co. Ltd.
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広瀬 勝己
Shionogi Research Laboratories Shionogi & Co. Ltd.
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石塚 夏樹
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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笹谷 隆司
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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牧角 徳夫
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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城山 博邦
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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畠山 久男
Shionogi Research Laboratories Shionogi & Co. Ltd.
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牧角 徳夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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畠山 久男
塩野義製薬 研
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石塚 夏樹
Shionogi Research Laboratories Shionogi & Co. Ltd.
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笹谷 隆司
Shionogi Research Laboratories Shionogi & Co. Ltd.
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城山 博邦
塩野義製薬 研
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