Studies on Fused Indoles. I. Novel Synthesis of 4-Aminomethyltetrahydrothiopyrano [2,3-b] indoles through a Thio-Claisen Rearrangement
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概要
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Two novel and simple methods for preparing 4-aminomethyl-2,3,4,9-tetrahydrothiopyrano [2,3-b] indoles are described. Both involve thio-Claisen rearrangements of indol-2-yl propargyl sulfides as a key step which affords thiopyrano [2,3-b] indoles in good yields. Elaboration of these compounds led to fused tryptamine analogues which were found to have strong analgesic activity. The mechanism of this novel rearrangement is discussed.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
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高田 進
Shionogi Research Laboratories Shionogi & Co. Ltd.
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牧角 徳夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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