Studies on Isoxazole Derivatives. XI. Synthesis of 4-Ethoxycarbonyl-and 4-Cyano-5-aminoisoxazoles and Their Ring Cleavage.
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概要
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4-Ethoxycarbonyl-(III) and 4-cyano-5-aminoisoxazole (IV) were prepared by reacting hydroxylamine and ethyl α-ethoxymethylenecyanoacetate (I) or α-ethoxymethylenemalononitrile (II), respectively. These 5-aminoisoxazoles were very unstable toward bases compared with a compound (XI) substituted in 3-position and the ring cleavage occurred at the nitrogen-oxygen bond with subsequent isomerisation to their corresponding nitriles, (V) and (VIII).
- 公益社団法人日本薬学会の論文
- 1958-02-20
著者
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牧角 徳夫
Research Laboratory, Shionogi & Co., Ltd.
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加納 日出夫
Shionogi Research Laboratory Shionogi & Co. Ltd.
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加納 日出夫
Research Laboratory Shionogi & Co. Ltd.
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牧角 徳夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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緒方 和子
Research Laboratory, Shionogi & Co., Ltd.
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緒方 和子
Research Laboratory Shionogi & Co. Ltd.
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