Pyridazines. VIII. Syntheses and Nuclear Magnetic Resonance Spectra of Cinnoline N-Oxides.

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概要

• 論文の詳細を見る

• Cinnoline 1-oxide (II), cinnoline 2-oxide (III), 4-methylcinnoline 1-oxide (V), 4-methylcinnoline 2-oxide (VI), 3-chlorocinnoline 1-oxide (VIII), and 3-methoxycinnoline 1-oxide (XXI) were synthesized. For confirmation of the structure of these compounds, cinnoline 1-oxide (II) and 3-chlorocinnoline 1-oxide (VIII) were prepared from their corresponding 5,6,7,8-tetrahydro derivatives (XI and XIII) by bromination with N-bromosuccimide followed by dehydrobromination with sodium methoxide. The structures of isomeric 4-methylcinnoline N-oxides were determined by the application of ultraviolet and nuclear magnetic resonance spectroscopies. The nuclear magnetic resonance spectra of the cinnoline N-oxides synthesized were examined. The interpretation of the spectra was made in connection with those of pyridazine N-oxides and of quinoline N-oxides. The proton H_8 shows its signal peak at a lower field than do the other protons, owing to the magnetic anisotropy effect of the N-O group.

• 公益社団法人日本薬学会の論文
• 1963-12-25

著者

• 尾形 秀

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 通 和夫

  Shionnogi Research Laboratory Shionogi and Co., Ltd.

• 加納 日出夫

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 加納 日出夫

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 尾形 秀

  Shionogi Research Laboratories Shionogi 〓 Co. Ltd.

• 通 和夫

  Shionogi Research Laboratory Shionogi & Co. Ltd.

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• Studies on Heteroaromatic N-Oxides. XI. Aminolysis of Esters of Benzazole N-Oxides and Related Quaternary Salts
• Heteroaromatic N-Oxides. X. Synthesis and Reactions of Benzothiazole 3-Oxide
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