Structures of Polygalacin-D and -D_2,Platycodin-D and -D_2,and Their Monoacetates, Saponins isolated from Platycodon grandiflorum A. DC., determined by Carbon-13 Nuclear Magnetic Resonance Spectroscopy
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概要
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The structure of new nine saponins isolated from Platycodon grandiflorum A. DC. have been elucidated by comparison of their ^<13>C nuclear magnetic resonance spectra with those of the known prosapogenins and that of platycodin-D (1). All the saponins proved to possess the same sugar chain as that of 1 at C-28 position. Eight of the nine (2,3,5,6,8,9,11,and 12) have an O-acetyl group which was found to migrate easily and reversibly between 2-O- and 3-O-position of the rhamnose moiety in their sugar chain. The other one is an acetyl-free saponin named polygalacin-D_2 (10). Two new deacetylated saponins, platycodin-D_2 (4) and polygalacin-D (7), were prepared from 5 (6) and 8 (9), respectively.
- 社団法人日本薬学会の論文
- 1978-02-25
著者
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東条 武彦
塩野義製薬
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吉村 洋子
Shionogi Research Laboratory Shionogi And Co. Ltd.
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石井 宏
Shionnogi Research Laboratory Shionogi and Co., Ltd.
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通 和夫
Shionnogi Research Laboratory Shionogi and Co., Ltd.
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東条 武彦
Shionnogi Research Laboratory Shionogi and Co., Ltd.
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石井 宏
Shionogi Research Laboratories Shionogi & Co. Ltd.
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通 和夫
Shionogi Research Laboratory Shionogi And Co. Ltd.
関連論文
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- Structures of Prosapogenins from Roots of Platycodon grandiflorum determined by Carbon-13 and Hydrogen-1 Nuclear Magnetic Resonance Spectroscopy
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