Isoxazoles. XXIII. Synthesis of N-Substituted 4-Isoxazolines and Their Conversion into 2-Acylaziridines
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概要
- 論文の詳細を見る
Synthesis and thermal-reaction of 4-isoxazolines were investigated. Reaction of 3-unsubstituted isoxazolium salts with sodium borohydride yielded the corresponding 4-isoxazolines and their borane complexes together with β-hydroxyaminopropiophenone derivatives. Analogous reaction of 5-unsubstituted isoxazolium salt yielded two isomeric products, 4- and 3-isoxazoline derivatives. The 3-isoxazoline derivative underwent further reduction to give isoxazolidine derivatives. Thermal-conversion of some 4-isoxazolines and their borane complexes into 2-acylaziridine derivatives is also reported.
- 公益社団法人日本薬学会の論文
- 1974-01-25
著者
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足達 郁夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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加納 日出夫
Shionogi Research Laboratory Shionogi & Co. Ltd.
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宮崎 理慧
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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