Phenothiazine Derivatives. I. Synthesis of Sulfoxide and Sulfone Homologs of Chlorpromazine.
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概要
- 論文の詳細を見る
The synthesis of theoretically possible four derivatives of chlorpromazine was described, in which the ring sulfur and then the nitrogen of lateral side chain were oxidized. The sulfone derivatives could not be derived from chlorpromazine itself, but could be prepared by the condensation of N, N-dimethyl-3-chloropropylamine with 2-chlorophenothiazine 5-dioxide, which was easily synthesized via 2-chloro-10-acetylphenothiazine.
- 公益社団法人日本薬学会の論文
- 1957-10-20
著者
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藤本 学
Research Laboratory Shionogi & Co. Ltd.
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加納 日出夫
Research Laboratory, Shionogi & Co., Ltd.
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加納 日出夫
Research Laboratory Shionogi & Co. Ltd.
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- Phenothiazine Derivatives. I. Synthesis of Sulfoxide and Sulfone Homologs of Chlorpromazine.
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