Synthesis of Potential Anticancer Agents. VI. Reactivity of 6-Bromo-s-triazolo [2,3-a] pyrimidines.
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概要
- 論文の詳細を見る
5-Hydroxy-6-bromo-7-amino- and 5,7-dihydroxy-6-bromo-s-triazolo [2,3-a] pyrimidines (III and IV) reacted with piperidine or morpholine to form the corresponding 6-piperidino-(V and VII) or morpholino-(VI and VIII) derivatives. Reaction of (IV) with thiourea gave the 6-amidinothio derivative (IX), which was converted into disulfide compound (X) by the action of alkali. Reaction of (III) with thiourea gave the 5-hydroxy-7-amino derivative (XII) and this reaction in alkaline medium gave the sulfide compound (XIII).
- 公益社団法人日本薬学会の論文
- 1961-10-25
著者
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牧角 徳夫
Research Laboratory, Shionogi & Co., Ltd.
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牧角 徳夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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