Carbanilide誘導体の合成とその抗菌性について

概要

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Reaction of 1-and 2-naphthols with 2-chloro-4-halonitrobenzene in diglyme, in the presence of sodium hydride, gave nitro compounds (I to VI) which were reduced with stannous chloride and hydrochloric acid to the amino compounds (VII to XII). These amino compounds were reacted with p-chlorophenyl isocyanate in ether and carbanilides (XIII to XVIII) were obtained. Other carbanilides (XIX to XXV) were obtained by reacting p-chlorophenyl isocyanate with 4,4'-diamino-4-methyldiphenylamine, 4-amino-4'-chlorophenyl sulfide, 2-amino-4,4'-dichlorodiphenylamine, 2-amino-4,4'-dichlorodi-phenyl sulfide, and 2-amino-4,4'-difluorodiphenyl ether, in the same way as above. Examination of antibacterial activity of these compounds showed that XV to XVII and XXII to XXIV had a strong antibacterial activity against gram-positive bacteria.
公益社団法人日本薬学会の論文
1976-05-25