新規な1,4-ジヒドロピリジン系Ca拮抗薬CS-905の研究(第1報)液体クロマトグラフ(HPLC)法による分配係数(logP)の測定
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概要
- 論文の詳細を見る
A new 1,4-dihydropyridine derivative, CS-905,currently under development as a Ca antagonist, showed a gradual onset and long duration in its antihypertensive effect upon single oral administration. The partition coefficient for CS-905 was measured along with 11 known dihydropyridine Ca antagonists by the HPLC method to clarify its mode of action. The log P_<HPLC> for CS-905 was, 5.18,almost the same as that of manidipine and this value is the highest among the measured drugs. Its pharmacokinetic profile in SHR was also discussed.
- 公益社団法人日本薬学会の論文
- 1995-03-25
著者
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古林 隆司
宇部興産株式会社宇部研究所
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大泉 喜代志
Sankyo Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.
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Oizumi K
Sankyo Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.
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益本 和枝
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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武安 明
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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大泉 喜代志
三共株式会社第一生物研究所第二室
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古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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- 新規な1,4-ジヒドロピリジン系Ca拮抗薬CS-905の研究(第1報)液体クロマトグラフ(HPLC)法による分配係数(logP)の測定
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