バナジウムのマウスにおける生体内挙動及び脂質過酸化反応への影響

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The distribution and effects of vanadium on the lipid peroxide level in the mouse lung, kidney and liver were investigated by short term inhalation of vanadium pentoxide aerosol (80 mg/m^3 as V_2O_5,1 h), a single oral and a single intraperitoneal (i. p.) administration of sodium vanadate (170 μmol/kg body weight as NaVO_3). The results obtained are as follows. 1. The highest distribution of vanadium was found in the lung in inhalation and in the kidney in case of oral and i. p. administration. 2. Accumulation and disappearance patterns of vanadium in the lung, kidney and liver were observed to have a similar tendency among 3 kinds of route of administration except lung of inhalation. That is, vanadium concentration in these tissues reached maximum value at 3 h after administration and decreased rapidly within 18 h, and then decreased slowly. 3. In the liver after i. p. administration, the highest distribution of vanadium was found in the 105000×g supernatant fraction at 3 h (64% of total fraction) and in the 10000×g pellet at 18 h (68% of total fraction). 4. Thiobarbituric acid (TBA) value, an index of lipid peroxidation, increased in the liver after inhalation and in the kidney and liver after i. p. administration at 0.5-3 h, 0.5-18 h and 7-18 h respectively. 5. The elevation of TBA value in the liver was recognized when hepatic glutathione concentrations was as high as 60-70% of control values.
社団法人日本薬学会の論文
1987-04-30