水銀化合物の代謝におよぼすセレンの影響

概要

論文の詳細を見る
Effect of selenium on metabolism of mercury compounds was examined, as it had been confirmed that selenium had a protective effect against the toxicity of mercuric chloride and methylmercuric chloride in rats. In rats receiving mercuric chloride with selenium, the mercury content in the liver was significantly increased compared with that in rats receiving mercuric chloride alone, and the selenium content in the liver was also increased compared with that in rats receiving selenium alone. The molar ratio of mercury to selenium in the liver was nearly 1.0. These results suggested that selenium interacted directly with mercuric chloride to form less toxic products in the rat liver. In rats receiving methylmercuric chloride with selenium, the percentage of methylmercury contentin total mercury in the liver was decreased compared with their percentage in rats receiving methylmercuric chloride alone.
公益社団法人日本薬学会の論文
1977-06-25