Effects of Calcium and Magnesium on the Anticoagulant Action of Heparin

概要

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The cooperative inhibitory action of heparin and antithrombin III on the thrombinfibrinogen reaction was neutralized by preincubating these anticoagulant factors in the presence of Ca or Mg, and the effect was larger with Ca than with Mg. However, the neutralizing action of Ca decreased in the presence of Mg. Bindings of poly-L-lysine and antithrombin III to heparin were also inhibited by the addition of Ca and Mg, and Ca had a larger effect than Mg. On the other hand, the binding ability of Ca to heparin was larger than that of Mg, and the coexistence of these metals reduced the binding affinity of each metal. These data suggest that the neutralizing action of Ca and Mg on the anticoagulant action of heparin and antithrombin III may be related to the ability of these metals to prevent the complex formation of the acid mucopolysaccharide and the thrombin inhibitor by binding to the acid mucopolysaccharide.
社団法人日本薬学会の論文
1983-09-25