(4-Nitroquinoline 1-Oxideの還元に及ぼすモリブテンの影響

概要

論文の詳細を見る
The effect of metals on the reduction of 4-nitroquinoline 1-oxide (4-NQO) was examined by using ascorbic acid as a reducing agent, and Fe(II), Cu(II), Zn(II), Mo(VI), Co(II), Mn(II), Cr(III), Al(III), and W(VI) as the metals. It was found that copper and molybdenum could reduce 4-NQO to 4-hydroxyaminoquino1ine 1-oxide (4-HAQO). It was further found that molybdenum was the only metal which was specific for the reduction of 4-HAQO to 4-aminoquinoline 1-oxide (4-AQO) among the metals examined. At a higher concentration of ascorbic acid, molybdenum reduced 4-HAQO to 4-aminoquinoline(4-AQ) via 4-AQO. The reduction mechanism of 4-HAQO by molybdenum was speculated as the facile reduction of 4-HAQO by the complex formation between 4-HAQO and molybdenum blue (reduced type of molybdenum). This result would support the role of molybdenum in the enzyme groups activated by molybdenum such as xanthine oxidase and nitrate reductase.
公益社団法人日本薬学会の論文
1975-08-25