Glucuronidesの生化学的研究(第2報) : p-Nitrophenyl GlucuronideのL-Ascorbic AcidあるいはHydrogenPeroxideによる解離生成物質の検討

概要

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The dissociation products of p-nitrophenyl glucuronide with L-ascorbic acid and cupric ion, or with hydrogen peroxide and cupric ion were identified as p-nitrophenol, 4-nitrocatechol, glucuronic acid, and glucaric acid which is a strong inhibitor of β-glucuronidase. It was assumed that p-nitrophenyl glucuronide was hydrolyzed to p-nitrophenol and glucuronic acid. With L-ascorbic acid and cupric ion or with hydrogen peroxide and cupric ion, glucuronic acid was oxidized easily to glucaric acid, and p-nitrophenol to 4-nitrocatechol. Therefore, 4-nitrocatechol and glucaric acid might be produced respectively from p-nitrophenol and glucuronic acid, which were the primary dissociation products of the glucuronide. However, it is also possible that p-nitrophenyl glucuronide is dissociated oxidatively to 4-nitrocatechol and glucaric acid.
公益社団法人日本薬学会の論文
1968-02-25