Studies on the Induction of DAB Metabolizing Enzyme Activity and Other Microsomal Enzyme Activity in the Liver of Rats fed Copper

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The mode of elevating action of 4-dimethylaminoazobenzene (DAB) metabolizing enzyme activity in the liver of rats fed copper was studied. The increases of the enzyme activity and flavin content were found with that of copper content in the liver homo-genates and microsomes of rats fed copper. But addition in vitro of cupric ion and/or fravin adenine dinucleotide (FAD) in the reaction mixture involving microsomal prepara-tions did not cause a marked enhancement of the enzyme activity. This fact is thought to indicate the both increases of flavin and apoenzyme. The concurrent administration of copper and 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) showed additive effect in reduced nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome c reductase activity and competitive effect in DAB azo reductase activity.
公益社団法人日本薬学会の論文
1975-07-25