Protective Effect of Sodium Molybbate against the Acute Toxicity of Mercuric Chloride in Rat. VI. : The Mechanism of Stimulative Action of Sodium Molybdate on Urinary Excretion of Mercury

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In order ot gain further insight into the protective action of Na_2MoO_4 pretreatment (1.24 mmol/kg, once a day, i.p.) against the acute toxicity of HgCl_2 (30 μmmol/mmol/kg, once, s.c.), changes of renal function, tissue accumulation of mercury, and urinary excretions of mercury and phenolsulfonphthalein after exposure to HgCl_2 were investigated. Lactate content in the kidney and serum calcium were also measured.Na_2MnO_4 pretreatment enhanced urinary excretion of mercury. Renal function of Na_2MoO_4-pretreated rats was better maintained as compared to that of the rats given HgCl_2 alone at either dose (30 or 15 μmol/kg) although the metal content in the kidney of this group was almost the same as that of the latter HgCl_2-alone rats. This pretreatment prevented the rise in lactate content in the kidney and the reduction of urinary excretion of phenolsulfonphthalein caused by HgCl_2. Na_2MoO_4 reduced serum calcium. These results suggest that Na_2MoO_4 prevented mercury-induced acute renal failure by decreasing tissue accumulation of the metal through urinary excretion of mercury. Better renal hemodynamics attributable to hypocalcalcemia may be a causative factor in the enhancement of urinary excretion of mercury.
社団法人日本薬学会の論文
1990-03-25