バナジウム投与マウスの肝及び腎臓における脂質過酸化反応について

概要

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The distribution patterns of thiobarbituric acid (TBA) reactive substances and vanadium in subcellular fractions of the liver and kidney of the mice administered with sodium vanadate were investigated at 3 h and 12 h after i.p. injection. The results obtained are as follows. (1) Among subcellular fractions of the liver and kidney, a remarkable enhancement of TBA reactive substances after the administration of vanadium was recognized in the liver supernatant fractions. That is, the elevation of TBA value in the liver supernatant at 3 h and 12 h after the administration were 21.8 and 13.4 times as large as the control one, respectively. (2) From the results of Sephadex G-75 gel chromatography, it was considered that TBA reactive substances in the liver supernatant exist at the high-molecular-weight fractions (molecular weight of 75000 or thereabout) and low-molecular-weight fractions (molecular weight of nearly 1500). Vanadium was found mainly at the eluated fractions of TBA reactive substances. But, vanadium in the low-molecular-weight fractions decreased rapidly. (3) Pretreatment with ascorbic acid did not suppress the formation of lipoperoxide in the liver supernatant after the administration of vanadium.
公益社団法人日本薬学会の論文
1991-02-28