Gastric-Mucous Membrane Protection Activity of Coptisine Derivatives
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概要
- 論文の詳細を見る
Coptisine and 8-oxocoptisine were isolated as principles of the gastric-mucous membrane protection from Coptidis rhizoma. The two compounds showed stronger activity than cimetidine and sucralfate. We prepared several derivatives having a partial structure of coptisine from commercially available starting materials. The compounds obtained were tested for gastric-mucous membrane protective activity and a correlation between activity and structure was studied. Our results suggest that the partial charge of the catechol skeleton is related to activity.
- 公益社団法人日本薬学会の論文
- 2001-11-01
著者
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YOKOI Toshio
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Yokoi T
Kobe‐gakuin Univ. Hyogo Jpn
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YAMAOKA Yumiko
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Yamaoka Yumiko
Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University
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Hirano H
Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University
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Yokoi Toshio
Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University
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HIRANO Hiroyuki
Faculty of Pharmaceutical Sciences and High-Technology Research Center, Kobe-Gakuin University
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OSAWA Eriko
Faculty of Pharmaceutical Sciences and High-Technology Research Center, Kobe-Gakuin University
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Osawa Eriko
Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University
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