Higher Yielding Isolation of Kinsenoside in Anoectochilus and Its Antihyperliposis Effect
スポンサーリンク
概要
- 論文の詳細を見る
A higher concentration of kinsenoside, 3-(R)-3-β-D-glucopyranosyloxybutanolide (1), was detected in the crude drug Anoectochilus formosanus, and A. koshunensis by HPLC analysis. A methylation reaction occurred to give methyl ester (4) when the lactone ring of 1 was cleaved by silica gel catalysis using methanol containing solvent used in the purification step resulting in difficulty to purify 1. To avoid the cleavage reaction, a reversed-phase or silica gel column without methanol was used to give a high yield of 1. In an anti-hyperliposis assay using high-fat diet rats, 1 significantly reduced the weights of body and liver, and also decreased the triglyceride level in the liver compared to those of control rats. On the other hand, the epimer of 1, 3-(S)-3-β-D-glucopyranosy-loxybutanolide (2), trivially named goodyeroside A, which was isolated from Goodyera species, had no effect for anti-hyperliposis. In aurothioglucose-induced obese mouse, 1 suppressed the body and liver weight increase, significantly ameliorated the triglyceride level in the liver, and also reduced the deposition of uterine fat-pads.
- 公益社団法人日本薬学会の論文
- 2001-01-01
著者
-
YOSHIZAWA Toyokichi
Seiwa Pharmaceutical Ltd.
-
Yoshizawa Toyokichi
Japan Seiwa Pharmaceutical Ltd.
-
Du X‐m
Research & Development Division Seiwa Pharmaceuticals Ltd.
-
Du Xiao-ming
Seiwa Pharmaceuticals Ltd.
-
Du Xiao-ming
正和薬品
-
Sugiura M
Japan Seiwa Pharmaceutical Ltd.
-
SHOYAMA Yukihiro
Graduate School of Pharmaceutical Sciences, Kyushu University
-
Sun Ning-yi
Japan Seiwa Pharmaceutical Ltd.
-
Du Xiao-Ming
Graduate School of Pharmaceutical Sciences, Kyushu University
-
TAMURA Takashi
Graduate School of Pharmaceutical Sciences, Kyushu University
-
MOHRI Atsushi
Japan, Seiwa Pharmaceutical Ltd.
-
SUGIURA Minoru
Japan, Seiwa Pharmaceutical Ltd.
-
IRINO Nobuto
Japan, Seiwa Pharmaceutical Ltd.
-
HAYASHI Jun
Graduate School of Medical Sciences, Kyushu University
-
Sugiura Minoru
Japan Seiwa Pharmaceutical Ltd.
-
Irino N
Seiwa Pharmaceuticals Ltd.
-
Mohri Atsushi
Japan Seiwa Pharmaceutical Ltd.
-
Tamura Takashi
Graduate School Of Engineering Tokyo Metropolitan University
-
Tamura T
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Shoyama Y
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagasaki International University
-
Shoyama Yukihiro
Graduate School Of Pharmaceutical Sciences Kyushu University
-
Hayashi Jun
Graduate School Of Medical Sciences Kyushu University
関連論文
- Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis(Pharmacognosy)
- Antinociceptive Activities of α-Truxillic Acid and β-Truxinic Acid Derivatives(Pharmacognosy)
- Anti-inflammatory Activity of 4,4'-Dihydroxy-α-truxillic Acid(Pharmacognosy)
- Quantitative Determination of Incarvillateine in Incarvillea sinensis by Solid Phase Extraction and High Performance Liquid Chromatography
- Anti-inflammatory Activities of α-Truxillic Acid Derivatives and Their Monomer Components(Medicinal Chemistry)
- A Monoterpene Alkaloid from Incarvillea sinensis
- Novel Prenylated Xanthones with Antioxidant Property from the Wood of Garcinia subelliptica
- A Novel Quinoline Alkaloid Possessing a 7-Benzyl Group from the Centipede, Scolopendra subspinipes
- Stereospecific and Regioselective Hydrolysis of Cannabinoid Esters by ES46.5K, an Esterase from Mouse Hepatic Microsomes, and Its Differences from Carboxylesterases of Rabbit and Porcine Liver(Biochemistry)
- Cross-Reactivity of Various Tetrahydrocannabinol Metabolites with a Monoclonal Antibody against Tetrahydrocannabinolic Acid
- Pharmacologically Active Saikosaponin in Bupleurum falcatum Detected by Competitive ELISA and Eastern Blotting Using Monoclonal Antibodies(Crop Physiology & Ecology)
- Eastern blotting and use of anti-saikosaponin a monoclonal antibodies for detection of saikosaponins
- Development of an Assay System for Saikosaponin a Using Antisaikosaponin a Monoclonal Antibodies(Pharmacognosy)
- Higher Yielding Isolation of Kinsenoside in Anoectochilus and Its Antihyperliposis Effect
- Glycosidic Constituents from in Vitro Anoectochilus formosanus
- Hepatoprotective Aliphatic Glycosides from Three Goodyera Species
- Pharmacological activities of crocin in saffron
- Construction and Expression of Specificity-Improved Single-Chain Variable Fragments against the Bioactive Naphthoquinone, Plumbagin(Pharmacognosy)
- フジバカマと称される2タイプの植物について
- Double Staining of Ginsenosides by Western Blotting Using Anti-ginsenoside Rb1 and Rg1 Monoclonal Antibodies
- Western Blotting for Ginseng Saponins, Ginsenosides Using Anti-ginsenoside Rb1 Monoclonal Antibody
- Species Identification of Licorice Using nrDNA and cpDNA Genetic Markers(Pharmacognosy)
- Constituent Properties of Licorices Derived from Glycyrrhiza uralensis, G. glabra, or G. inflata Identified by Genetic Information(Pharmacognosy)
- Pharmacologically active compounds in the Anoectochilus and Goodyera species
- The Effects of Ethanol and Crocin on the Induction of Long-Term Potentiation in the CA1 Region of Rat Hippocampal Slices
- Cloning of THCA Synthase Gene and Its Distribution
- Expression of a spinach gene encoding a cysteine synthase-like protein in tobacco plants
- Effect of Tilted Edges on Coupled Vibrations of Doubly Rotated Quartz Plates
- Distribution of Solasodine Glycosides in Solanum khasianum Fruiting Stage Determined by ELISA and Western Blotting
- Survey of Solasodine-Type Glycoalkaloids by Western Blotting and ELISA Using Anti-solamargine Monoclonal Antibody
- Enhanced Sensitivity of a Surface-plasmon-resonance (SPR) Sensor for 2,4-D by Controlled Functionalization of Self-assembled Monolayer-based Immunosensor Chip
- The Role of Cysteine 116 in the Active Site of the Antitumor Enzyme L-Methionine γ-Lyase from Pseudomonas putida
- The Role of Cysteine 116 in the Active Site of the Antitumor Enzyme L-Methionine γ-Lyase from Pseudomonas putida
- Clonal Propagation of Quercus acutissima Carruth by Somatic Embryogenesis from Embyonic Axes
- Western Blotting Method for the Immunostaining Detection of Glucuronides of Glycyrrhetic Acid Using Anti-Glycyrrhizin Monoclonal Antibody
- Quantitative analysis of ginsenosides Rb1, Rg1, and Re in American ginseng berry and flower samples by ELISA using monoclonal antibodies
- Detection and quantification of ginsenoside Re in ginseng samples by a chromatographic immunostaining method using monoclonal antibody against ginsenoside Re
- A Quantitative ELISA Using Monoclonal Antibody to Survey Paeoniflorin and Albiflorin in Crude Drugs and Traditional Chinese Herbal Medicines
- Phenolics from Epimedium diphyllum(Natural Medicine Note)
- Single-chain variable fragment antibody against ginsenoside Re as an effective tool for the determination of ginsenosides in various ginsengs
- Distribution of Solasodine Glycosides in Solanum khasianum Fruiting Stage Determined by ELISA and Western Blotting
- The Role of Amino Acid Residues in the Active Site of L-Methionine γ-lyase from Pseudomonas putida
- The Role of Amino Acid Residues in the Active Site of L-Methionine γ-lyase from Pseudomonas putida
- Rapid Identification of Mycoplasma pulmonis Isolated from Laboratory Mice and Rats Using Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry
- Effect of Tilted Edges on Coupled Vibrations of Doubly Rotated Quartz Plates