Hepatoprotective Aliphatic Glycosides from Three Goodyera Species
スポンサーリンク
概要
- 論文の詳細を見る
Hepatoprotective aliphatic glycosides 3-(S)-3-β-D-glucopyranosyloxybutanolide (1) and its congener, 3-(S)-3-β-D-glucopyranosyloxy-4-hydroxybutanoic acid (2) were isolated as major constituents from the whole plants of three Goodyera species, G. schlechtendaliana REICHB. fil., G. matsumurana SCHLTR. and G. discolor KER-GAWL. The structures of 1 and 2 have been determined by NMR, MS spectroscopic and chemical means. Compound 1 was converted into its methyl ester form (5) during the purification step, when the lactone ring was cleaved by catalysis of silica gel with the CHCl_3-MeOH-H_2O as a solvent. On the other hand, 1 was obtained in a high yield by the same purification procedure without MeOH. Based on this fact, a simple and economic method for the purification of 1 was confirmed. Compounds 1 and 2 were found to have a hepatoprotective effect on liver injury induced by carbon tetrachloride in primary cultured rat hepatocytes.
- 公益社団法人日本薬学会の論文
- 2000-06-01
著者
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Du X‐m
Research & Development Division Seiwa Pharmaceuticals Ltd.
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Du Xiao-ming
Seiwa Pharmaceuticals Ltd.
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Du Xiao-ming
正和薬品
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SHOYAMA Yukihiro
Graduate School of Pharmaceutical Sciences, Kyushu University
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Sun Ning-yi
Japan Seiwa Pharmaceutical Ltd.
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Du Xiao-Ming
Graduate School of Pharmaceutical Sciences, Kyushu University
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SUN Ning-Yi
Seiwa Pharmaceutical Ltd.,
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IRINO Nobuto
Seiwa Pharmaceutical Ltd.,
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CHEN Yang
Graduate School of Pharmaceutical Sciences, Kyushu Universty
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Irino N
Seiwa Pharmaceuticals Ltd.
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Shoyama Y
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagasaki International University
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Shoyama Yukihiro
Graduate School Of Pharmaceutical Sciences Kyushu University
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Chen Yang
Graduate School Of Pharmaceutical Sciences Kyushu Universty
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CHEN Yang
Graduate School of Information Science, Nagoya University
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