On the Solute-Stationary Phase Interaction in Gas-Liquid Chromatorgaphy. Evaluation on the Relative Retention Values for Mono- and Polyalkyo-Substituted Benzene Derivatives
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概要
- 論文の詳細を見る
The values of log γ for monosubstituted benzene derivatives can be expressed after regression analyses by a linear combination of the quantitative structure-activity relationship (QSAR) descriptors σ_<s°>, μ^2/α, and σ^±_π. The inclusion of aniline series derivatives demands and additional descriptor pK_a, ascribed to the CH/N interaction between the stationary liquid and the nitrogen lone pair. Furthermore, for all cases of polyalkylvenzene derivatives, the descriptor σ_<s°> is effective, and the number of vicinal type CH_3-pairs represented at first by the descriptor ortho numver N_o can be transformed to the corrected σ^+_π, representing the CH/π type charge-transfer interaction between the substrate and the stationary liquid.
- 公益社団法人日本薬学会の論文
- 1990-03-25
著者
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川木 秀子
Faculty of Pharmaceutical Sciences, Kinki University
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佐々木 喜男
Faculty of Pharmaceutical Sciences, Osaka University
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佐々木 喜男
Faculty Of Pharmaceutical Sciences Osaka University
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高木 達也
Faculty of Pharmaceutical Sciences, Osaka University
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村上 亨
Faculty Of Pharmaceutical Sciences Osaka University
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高木 達也
Genome Information Research Center Osaka University
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藤井 志保
Faculty of Pharmaceutical Sciences, Osaka University
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升田 史佳
Faculty of Pharmaceutical Sciences, Osaka University
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藤井 志保
Faculty Of Pharmaceutical Sciences Osaka University
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川木 秀子
Faculty Of Pharmaceutical Sciences Kinki University
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升田 史佳
Faculty Of Pharmaceutical Sciences Osaka University
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