Substitutent Entropy constant σ_<s°> and Descriptor μ^2/α of sym-Disubstituted Benzene Derivatives. : Estimation and Validity of Novel Quantitative Structure-Activity Relationships Descriptors
スポンサーリンク
概要
- 論文の詳細を見る
The values of substituent entropy constant σ_<s°> of sym-disubstituted benzene derivatives have been determined by inter- or extrapolation of the linear relation between five observed values and those of monosubstituted benzene derivatives.Analysis of the quantitative structure-activity relationships (QSAR) by means for σ_<s°> thus estimated, together with the additional descriptor μ^2/α, is shown to be more effective than approaches hitherto used for the evaluation of actinidin-catalyzed hydrolysis of substituted phenyl hippurates, and the reaction between thiamine and substituted aniline derivatives with hiaminase.
- 公益社団法人日本薬学会の論文
- 1988-12-25
著者
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川木 秀子
Faculty of Pharmaceutical Sciences, Kinki University
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佐々木 喜男
Faculty of Pharmaceutical Sciences, Osaka University
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佐々木 喜男
Faculty Of Pharmaceutical Sciences Osaka University
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升田 史佳
Faculty of Pharmaceutical Sciences, Osaka University
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川木 秀子
Faculty Of Pharmaceutical Sciences Kinki University
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升田 史佳
Faculty Of Pharmaceutical Sciences Osaka University
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