Stereochemistry of Quinolizidines. V. Protonation of Benzo [α] quinolizidines and Determination of Their Nitrogen Inversion Rates
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概要
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The nitrogen inversion rate of 1,2,3,4,6,7-hexahydro-11bH-benzo [α] quinolizine (I) is determined by means of line broadening of ^<13>C FT nuclear magnetic resonance under the successive alteration of pD. The k_<trans> thus obtained was confirmed to be reasonable but k_<cis> was presumed to be smaller than the actual one, which is responsible to the difference of pK_a between trans- and cis "a"-conformer. Actually, it was realized for benzo [α]-quinolizidines that trans-conformer takes lower pK_a than that of cis "a"-conformer because of the steric effect.
- 社団法人日本薬学会の論文
- 1978-08-25
著者
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藤原 英明
大阪大 医
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佐々木 喜男
Faculty of Pharmaceutical Sciences, Osaka University
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佐々木 喜男
Faculty Of Pharmaceutical Sciences Osaka University
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杉浦 真喜子
Kobe Women's College Of Pharmacy
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高尾 楢雄
Kobe Women's College of Pharmacy
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高尾 楢雄
Kobe Women's College Of Pharmacy
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