Studies on the Nuclear Magnetic Resonance Spectra in Aliphatic Systems. I. Preliminary Discussions on the Chemical Shifts of Alkyl Derivatives
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概要
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Proton chemical shifts in alkyl-R compounds are examined with respect to substituent constants and following results are obtained. 1) α-^1H chemical shifts are linear with σ_i-0.25 σ_π except for nitro group of isopropyl-R series, CN and halogen group. 2) β-^1H chemical shifts are linear with σ_i. These results indicate that 20% π-electronic together with 80% σ-electronic effect takes part in determining α-^1H chemical shifts, on the other hand β-^1H chemical shifts are dependent mainly on σ-electronic effect. The deviations observed for halogen and cyano groups indicate that induced current effects on α-^1H are diamagnetic in character. The effective shielding constants and substituent electronegativities are also linear with σ_i-0.25σ_π.
- 公益社団法人日本薬学会の論文
- 1968-11-25
著者
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鈴木 美代子
Faculty Of Pharmaceutical Sciences Osaka University
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佐々木 喜男
Faculty Of Pharmaceutical Sciences Osaka University
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尾崎 茂子
Faculty Of Pharmaceutical Sciences Osaka University
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