Remarkably Enhanced Inhibitory Effects of Three-Component Hybrid Liposomes Including Sugar Surfactants on the Growth of Lung Carcinoma Cells
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概要
- 論文の詳細を見る
Sugar parts play important roles in recognizing molecules on the cell membranes. We successfully produced sugar-type micellar surfactants, lactonoalkylamide (LacC_n), for the first time. Spherical vesicles, three-component hybrid liposomes, were obtained after the sonication of the mixture of L-α-dimyristoyl-phosphatidylcholine (DMPC), Tween 20 and LacC_n (DMPC : Tween 20 : LacC_n=65:7:28). It is noteworthy that high in-hibitory effects of the three-component hybrid liposomes composed of DMPC, Tween 20, and LacC_n (DMPC : Tween 20 : LacC_n=65: 7 : 28) on the growth of glioma (U251) and lung adenocarcinoma (RERF-LC-OK) cells were attained in vitro without any drug, although no significant inhibitory effects of any individual component (DMPC, Tween 20, LacC_n) or the two-component hybrid liposomes of DMPC and Tween 20 on the growth of tumor cells examined were obtained.
- 公益社団法人日本薬学会の論文
- 2002-04-01
著者
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GOTO Masahiro
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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Goto K
Graduate Course Of Applied Life Science Sojo University
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松本 陽子
崇城大学大学院工学研究科応用生命科学専攻
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上岡 龍一
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Matsumoto Y
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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古崎 新太郎
崇城大学工学部応用生命科学科
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Goto Koichi
Graduate Course Of Applied Life Science Sojo University
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MATSUMOTO Yoko
Graduate Course of Applied Life Science, Sojo University
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UEOKA Ryuichi
Graduate Course of Applied Life Science, Sojo University
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Furusaki Shintaro
Graduate School Of Engineering The University Of Tokyo
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Furusaki Shintaro
Department Of Applied Life Science Faculty Of Engineering Sojo University
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Goto Masahiro
Department Of Applied Chemistry Graduate School Of Engineering Kyushu University
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松本 宣明
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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HIROSE Shigeru
Graduate Course of Applied Chemistry, Solo University
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Ueoka Ryuichi
Graduate Course Of Applied Chemistry Kumamoto Institute Of Technology
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Hirose S
Graduate Course Of Applied Chemistry Solo University
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Goto K
Div. Of Applied Life Sci. Graduate School Of Engineering Sojo Univ.
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Matsumoto Yoko
Graduate Course Of Applied Life Science Sojo University
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Goto Masahiro
Department Of Applied Biological Chemistry The University Of Tokyo
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Goto Masahiro
Department Of Applied Chemistry Class Of Molecular System Engineering Kyushu University
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Matsumoto Yoko
Graduate Course of Applied Chemistry, Sojo University
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