Steric-Control for the Enantioselective Hydrolysis of Amino Acid Esters in Hybrid Membrane Systems
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概要
- 論文の詳細を見る
The enantioselective hydrolysis of the amino acid esters, p-nitrophenyl-N-dodecanoyl-D(L)-phenylalaninates (C_12-D(L)-Phe-PNP) catalyzed by active tripeptide, N-(benzyloxycarbonyl)-L-phenylalanyl-L-histidyl-L-leucine (Z-PheHisLeu) in the presence of coaggregates (hybrid membranes) composed of native phospholipid, L-α-dimyris-toylphosphatidylcholine (DMPC) and nonionic surfactant, polyoxyethylene (8) lauryl ether (C_12(EO)_8) was easily controlled by regulating the reaction temperature and changing the composition of coaggregates. Furthermore, excellent correlations were observed between the enantioselectivity in the hydrolysis of C_12-D(L)-Phe-PNP catalyzed by Z-PheHisLeu in the presence of coaggregates and physical properties of hybrid membranes. It is assumed that catalytic activities of tripeptide catalyst in hybrid membranes should be regulated by changing the microenvironments of reaction fields.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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GOTO Koichi
Division of Thoracic Oncology, National Cancer Center Hospital East
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Goto K
Graduate Course Of Applied Life Science Sojo University
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Goto Koichi
Division Of Cardiology Sakurabashi Watanabe Hospital
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松本 陽子
崇城大学大学院工学研究科応用生命科学専攻
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上岡 龍一
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Matsumoto Y
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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ICHIHARA Hideaki
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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MATSUMOTO Yoko
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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松本 宣明
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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TANOUE Osamu
Department of Applied Life Science, Sojo University
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UEOKA Ryuichi
Department of Applied Life Science, Sojo University
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Tanoue Osamu
Sojo University
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Goto K
Div. Of Applied Life Sci. Graduate School Of Engineering Sojo Univ.
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Goto Koichi
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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