Cyclodextrin-Mediated Deacylation of Amino Acid Esters with Marked Stereoselectivity
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概要
- 論文の詳細を見る
With respect to the hydrolysis (deacylation) of Z-D(L)-amino acid esters (N-(benzyloxycarbonyl)-D(L)-amino acid p-nitrophenyl esters) mediated by α-,β- and γ-cyclodextrins (CyDs), a remarkably high enantioselectivity (L/D=9.0) was observed for the deacylation of Ala substrate with γ-CyD. The kinetic results on the basis of the Michnelis-Menten principle indicate that the enantioselectivity should be mainly originated in the deacylation process of substrates following the formation of γ-CyD-substrate (1:1) complexes. The computer modeling (molecular mechanics) studies on the inclusion complexes are also described.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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GOTO Koichi
Division of Thoracic Oncology, National Cancer Center Hospital East
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Goto K
Graduate Course Of Applied Life Science Sojo University
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Goto Koichi
Division Of Cardiology Sakurabashi Watanabe Hospital
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松本 陽子
崇城大学大学院工学研究科応用生命科学専攻
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上岡 龍一
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Matsumoto Y
Department Of Clinical Pharmacology And Toxicology Showa Pharmaceutical University
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UEOKA Ryuichi
Division of Applied Chemistry, Graduate School of Kumamoto Institute of Technology
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TANOUE Osamu
Division of Applied Chemistry, Graduate School of Kumamoto Institute of Technology
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IMAMURA Chikara
Department of Human Environment, Yamaguchi Prefectural University
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IHARA Yasuji
Department of Human Environment, Yamaguchi Prefectural University
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MATSUMOTO Yoko
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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松本 宣明
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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NAKASHIMA Kentaro
Division of Applied Chemistry, Graduate School of Sojo University(former name
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NUKUSHINA Satoshi
Division of Applied Chemistry, Graduate School of Sojo University(former name
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TOUDO Isao
Division of Applied Chemistry, Graduate School of Sojo University(former name
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Toudo Isao
Division Of Applied Chemistry Graduate School Of Sojo University(former Name:kumamoto Institute Of T
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Tanoue Osamu
Sojo University
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Ihara Y
Department Of Human Environment Yamaguchi Prefectural University
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Goto K
Div. Of Applied Life Sci. Graduate School Of Engineering Sojo Univ.
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Ihara Yasuji
Department Of Human Environment Yamaguchi Prefectural University
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Nukushina Satoshi
Division Of Applied Chemistry Graduate School Of Sojo University(former Name:kumamoto Institute Of T
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Nakashima Kentaro
Division Of Applied Chemistry Graduate School Of Sojo University(former Name:kumamoto Institute Of T
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Imamura Chikara
Department Of Human Environment Yamaguchi Prefectural University
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Goto Koichi
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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