ハイブリッド型リポソームの種々の腫瘍細胞に対する特異的増殖抑制効果

概要

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The inhibitory effects of hybrid liposomes composed of lipids having a variety of head groups (zwitterionic L-α-dimyristoylphosphatidylcholine (DMPC), anionic L-α-dimyristoylphosphatidylglycerol (DMPG), and cationic 1,2-dimyristoyl-3-trimethylammonium propane (DMTAP)) and polyoxyethylene (10) dodecyl ether (C_<12>(EO)_<10>) on the growth of tumor cells (human lung carcinoma (RERF-LC-OK), human hepatoma (Hep-G_2), human stomach tumor (GT3TKB)) in vitro were examined. The hybrid liposomes of DMPC/10 mol % C_<12>(EO)_<10> and DMPG/10 mol % C_<12>(EO)_<10> were fairly more effective for inhibiting the growth of all tumor cells employed in this study as compared with liposomes (DMPC and DMPG) or micelles (C_<12>(EO)_<10>). Especially, it is attractive that the highly specific inhibitory effect of the hybrid liposomes of DMPG/10 mol % C_<12>(EO)_<10> without any antitumor drugs on the growth of RERF-LC-OK and GT3TKB was obtained for the first time.
社団法人日本薬学会の論文
1999-04-01